New Post-baccalaureate Fellowship / Technician Position
The Kelada Lab is recruiting for a new technician to be involved in experiments with an in vitro cell culture model to identify genes that influence responses to exposures that induce asthma and/or COPD. The applicant will be trained in detail on the cell culture model, learn and apply methods of experimental design, and have the opportunity to learn and conduct statistical analysis of data generated. This is an ideal job for an applicant taking time between undergraduate and graduate/professional school and will provide ample opportunities to learn highly valuable analytical and communication skills. Applicants that join the lab will have the option to join UNC’s new Post-baccalaureate Research Initiative in Science and Medicine (PRISM). The PRISM program provides research (lab-based) and didactic training opportunities, and includes programming to facilitate trainee’s graduate school applications.
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New Post-doctoral Fellowship Position
We’re recruiting for a post-doctoral fellow to join the lab’s research program on genetic and genomic determinants of air pollution response. The overall goal of a new, NIH-funded project is to identify interactions between the genome (i.e., DNA sequence variants) and exposure to the common air pollutant ozone affect the epigenome and transcriptome in different cell types of the murine lung. Through subsequent, integrative analyses, we will then examine how these interactions influence the development of acute and chronic respiratory disease phenotypes in our genetically diverse mouse model system.
The post-doctoral fellow will lead our efforts to generate and analyze these genetic and genomic datasets, working collaboratively with other lab members and collaborators on campus. The data generation phase will include exposing mice to ozone and collecting respiratory epithelial cells and alveolar macrophages using flow sorting, following by preparation of samples for RNA-seq and ATAC-seq. The data analysis phase will include differential gene and chromatin accessibility analysis, and quantitative trait locus (QTL) mapping of ozone-induced respiratory disease phenotypes. The data generation (wet lab) and analysis (dry lab) phases will comprise approximately 30% and 70% of research effort, respectively, and can be modified depending on the applicant’s prior experience and training goals.
In total, this post-doctoral fellowship will provide a motivated trainee with the opportunity to further develop research and communication skills that will allow them to springboard to research careers in academia and elsewhere.
So, if you’re interested in themes of gene-environment interaction, environmental influences on the transcriptome and epigenome, and/or air pollution-induced lung disease, please reach out. The job posting is here, and you will need to submit the follow materials to apply:
- Curriculum Vitae
- Cover letter with a brief statement of research interests
- List of references with contact information
- A sample of scientific writing from graduate training (e.g., published manuscript or chapter from dissertation)